Hypoglycemic Detection at the Portal Vein: Absent in Humans or Yet to Be Elucidated?
نویسندگان
چکیده
منابع مشابه
Hypoglycemic Detection at the Portal Vein
With the advent of more intensive glucose management, hypoglycemia has emerged as a primary limitation in the treatment of insulindependent diabetes. It is now recognized that the increased incidence of hypoglycemia derives not only from imperfect insulin replacement but also from impaired counterregulation and hypoglycemic unawareness (1). The latter two observations have led to a renewed inte...
متن کاملMetabolic sensors mediate hypoglycemic detection at the portal vein.
The current study sought to ascertain whether portal vein glucose sensing is mediated by a metabolic fuel sensor analogous to other metabolic sensors presumed to mediate hypoglycemic detection (e.g., hypothalamic metabosensors). We examined the impact of selectively elevating portal vein concentrations of lactate, pyruvate, or beta-hydroxybutyrate (BHB) on the sympathoadrenal response to insuli...
متن کاملNovel glucosensor for hypoglycemic detection localized to the portal vein.
In this investigation, we sought to constrain the locus of essential portohepatic glucosensors and test the hypothesis that they reside strictly in the portal vein and not the liver. Male Wistar rats were chronically cannulated in the carotid artery (sampling), jugular vein (infusion), and portal vein, either adjacent to (POR[ADJ], 0.6 +/- 0.1 cm, n = 6) or upstream from (POR[UPS], 2.7 +/- 0.1 ...
متن کاملHypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons.
To elucidate the type of spinal afferent involved in hypoglycemic detection at the portal vein, we considered the potential role of capsaicin-sensitive primary sensory neurons. Specifically, we examined the effect of capsaicin-induced ablation of portal vein afferents on the sympathoadrenal response to hypoglycemia. Under anesthesia, the portal vein was isolated in rats and either capsaicin (CA...
متن کاملHypoglycemic detection does not occur in the hepatic artery or liver: findings consistent with a portal vein glucosensor locus.
Our laboratory has previously demonstrated that hypoglycemic detection occurs in the portal vein, not the liver. To ascertain whether hypoglycemic detection may also occur in the hepatic artery, normoglycemia was established across the liver via a localized hepatic artery glucose infusion. Male mongrel dogs (n = 7) were infused with insulin (5.0 mU x kg(-1) x min(-1)) via the jugular vein to in...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2008
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-1437